Exploring the relationships between inflammatory response and coagulation cascade in inflammatory bowel disease

Eur Rev Med Pharmacol Sci. Sep-Oct 2004;8(5):205-8.


Background: The inflammatory network and the coagulation cascade are strictly correlated biological systems. Inflammatory Bowel Diseases (IBD) are characterised by a prothrombotic state, a hypercoagulability state and an increased prevalence of thromboembolic events.

Methods: We reviewed the IBD literature in which the relationships between inflammation and coagulation were evaluated.

Results: Several risk factors and mechanisms have been suggested to be implicated in determining the increased risk for thrombosis of IBD. Even if IBD may be per se a prothrombotic condition, systemic inflammation and vitamin deficiencies appear to play a relevant role in determining such a risk.

Conclusions: A good and continuous control of the intestinal disease and vitamin supplementation are strongly recommended in order to correct some of the risk factors for thrombosis in IBD patients.

Publication types

  • Review

MeSH terms

  • Blood Coagulation / physiology*
  • Blood Coagulation Disorders / complications
  • Humans
  • Inflammation Mediators
  • Inflammatory Bowel Diseases / blood*
  • Inflammatory Bowel Diseases / pathology*
  • Thrombosis / complications


  • Inflammation Mediators