Synthesis of 2,3-disubstituted indole on solid phase by the Fischer indole synthesis

J Comb Chem. 2005 Jan-Feb;7(1):130-5. doi: 10.1021/cc049922e.

Abstract

2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon-carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Indoles / chemical synthesis*
  • Indoles / chemistry*
  • Molecular Structure

Substances

  • Indoles