Hypothalamic-pituitary-adrenal and autonomic nervous system functioning in fibromyalgia

Rheum Dis Clin North Am. 2005 Feb;31(1):187-202, xi. doi: 10.1016/j.rdc.2004.10.002.


In general, there seems to be a reduction in some neuroendocrine and autonomic nervous system (ANS) responses to applied stresses in individuals who have fibromyalgia. This article presents an overview and discussion of these findings with respect to the role of the ANS and the neuroendocrine system in the response to stress, with emphasis on the hypothalamic-pituitary-adrenal axis and the possible implication to fibromyalgia.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System / physiopathology*
  • Fatigue / etiology
  • Fatigue / physiopathology
  • Fibromyalgia / etiology
  • Fibromyalgia / physiopathology*
  • Fibromyalgia / therapy
  • Humans
  • Neurosecretory Systems / physiopathology*
  • Pain / etiology
  • Pain / physiopathology
  • Pituitary-Adrenal System / physiopathology*
  • Stress, Physiological / complications
  • Stress, Physiological / physiopathology