15d-PGJ2: the anti-inflammatory prostaglandin?

Clin Immunol. 2005 Feb;114(2):100-9. doi: 10.1016/j.clim.2004.09.008.


15-Deoxy-Delta-12,14-prostaglandin J2 (15d-PGJ2) is the most recently discovered prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other prostaglandins in several respects. There is no specific prostaglandin synthase (PGS) leading to 15d-PGJ2 production and no specific 15d-PGJ2 receptor has been identified to date. Instead, 15d-PGJ2 has been shown to act via PGD2 receptors (DP1 and DP2) and through interaction with intracellular targets. In particular, 15d-PGJ2 is recognized as the endogenous ligand for the intranuclear receptor PPARgamma. This property is responsible for many of the 15d-PGJ2 anti-inflammatory functions. In this review, we summarize the current understanding of 15d-PGJ2 synthesis, biology and main effects both in molecular physiology and pathological states.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Humans
  • Inflammation / immunology
  • NF-kappa B / immunology
  • PPAR gamma / immunology*
  • Prostaglandin D2 / analogs & derivatives*
  • Prostaglandin D2 / biosynthesis
  • Prostaglandin D2 / immunology*
  • Prostaglandin-Endoperoxide Synthases / metabolism


  • 15-deoxyprostaglandin J2
  • NF-kappa B
  • PPAR gamma
  • Prostaglandin-Endoperoxide Synthases
  • Prostaglandin D2