Pulmonary regurgitation: not a benign lesion

Eur Heart J. 2005 Mar;26(5):433-9. doi: 10.1093/eurheartj/ehi091. Epub 2005 Jan 7.


Pulmonary regurgitation (PR) is a common complication after surgical or percutaneous relief of pulmonary stenosis and following repair of tetralogy of Fallot. Significant PR is usually well tolerated in childhood. However, in the long term, chronic PR has a detrimental effect on right ventricular (RV) function and exercise capacity and leads to an increased risk of arrhythmia and sudden cardiac death (SCD). Recent advances in non-invasive imaging and, in particular, wider availability of cardiovascular magnetic resonance (CMR), have improved the assessment of PR and RV function in these patients. This in turn has facilitated decision making on the optimal timing for elective pulmonary valve replacement (PVR), which should be performed before irreversible RV dysfunction ensues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arrhythmias, Cardiac / etiology
  • Arrhythmias, Cardiac / prevention & control
  • Death, Sudden, Cardiac / etiology
  • Death, Sudden, Cardiac / prevention & control
  • Echocardiography
  • Electrocardiography
  • Exercise Test
  • Exercise Tolerance
  • Heart Valve Prosthesis Implantation*
  • Humans
  • Magnetic Resonance Angiography / methods
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology*
  • Postoperative Complications / therapy
  • Pulmonary Valve / abnormalities
  • Pulmonary Valve Insufficiency / diagnosis
  • Pulmonary Valve Insufficiency / etiology*
  • Pulmonary Valve Insufficiency / therapy
  • Pulmonary Valve Stenosis / complications
  • Pulmonary Valve Stenosis / surgery*
  • Tetralogy of Fallot / complications
  • Tetralogy of Fallot / surgery*
  • Ventricular Dysfunction, Right / etiology