High-performance liquid chromatographic method for the analysis of Oltipraz in human serum and urine

J Chromatogr. 1992 Jan 3;573(1):146-9. doi: 10.1016/0378-4347(92)80488-c.


A rapid, sensitive procedure for the analysis of Oltipraz in serum and urine using high-performance liquid chromatography was developed. The proposed method illustrates recovery of Oltipraz from biological fluids was greater than 80%. Detection and separation of Oltipraz required as little as 1 ml of serum or urine. Oltipraz was detectable when 2 ng or more of drug was present in 1 ml of serum or urine; the method is highly reproducible when 5 ng/ml or more Oltipraz is present in the biological fluid.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Humans
  • Pyrazines / analysis*
  • Pyrazines / blood
  • Pyrazines / urine
  • Quality Control
  • Reference Standards
  • Thiones
  • Thiophenes


  • Pyrazines
  • Thiones
  • Thiophenes
  • oltipraz