New highlights on stroma-epithelial interactions in breast cancer

Breast Cancer Res. 2005;7(1):33-6. doi: 10.1186/bcr972. Epub 2004 Nov 25.


Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / physiopathology*
  • Cell Communication*
  • Cell Transformation, Neoplastic
  • Epithelial Cells / physiology*
  • Female
  • Humans
  • Mammary Glands, Animal / growth & development
  • Mammary Glands, Human / growth & development
  • Mice
  • Signal Transduction
  • Stromal Cells / physiology*
  • Transforming Growth Factor beta / physiology


  • Transforming Growth Factor beta