Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes

EMBO Rep. 2005 Jan;6(1):22-7. doi: 10.1038/sj.embor.7400319.


Synapse-associated proteins that are located at the postsynaptic density (PSD) have recently been shown to have a structural role at non-synaptic locations. Here, they act as adaptor proteins between neurotransmitter receptors and the microtubule- or microfilament-based motor-protein complexes that are responsible for transport to the PSD. The use of a common set of proteins that contain multiple domains for protein-protein interactions as both intracellular transport adaptors and synaptic scaffold proteins might contribute to the transport specificity and postsynaptic integration of receptors that underlie synapse formation and plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Microtubules / metabolism
  • Neurons / metabolism*
  • Protein Transport
  • Synapses / chemistry
  • Synapses / metabolism