An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry

Aliment Pharmacol Ther. 2005 Jan 1;21(1):29-34. doi: 10.1111/j.1365-2036.2004.02298.x.


Background: Alginate-based preparations act as mechanical antireflux barrier, which can reduce both acid and non-acid reflux events and limit the proximal migration of oesophageal refluxate.

Aim: To evaluate all the above features with a novel technique, multichannel electrical impedance and pH-metry.

Methods: Ten reflux patients underwent stationary impedancemetry and pH-metry after eating a refluxogenic meal. They were studied 1 h in basal conditions and 1 h after taking 10 mL of Gaviscon Advance. In both sessions, measurements were obtained in right lateral and supine decubitus.

Results: Alginate preparation was able to decrease significantly (P < 0.05) the number of acid reflux events and the percentage time pH < 4.0 compared with baseline. There was no effect of the drug on non-acid refluxes. Gaviscon Advance was also significantly effective (P < 0.05) in reducing the height of proximal migration of reflux events compared with baseline in both decubitus positions.

Conclusions: Our findings explain how Gaviscon Advance controls acid reflux episodes, limits the proximal migration of refluxed material and thereby decreases symptoms in clinical practice.

MeSH terms

  • Adult
  • Aged
  • Alginates / therapeutic use*
  • Aluminum Hydroxide / therapeutic use*
  • Antacids / therapeutic use*
  • Drug Combinations
  • Drug Evaluation
  • Female
  • Gastric Acid / metabolism
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Silicic Acid / therapeutic use*
  • Sodium Bicarbonate / therapeutic use*


  • Alginates
  • Antacids
  • Drug Combinations
  • Silicic Acid
  • Aluminum Hydroxide
  • alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
  • Sodium Bicarbonate