Ethnic differences in cerebral venous thrombosis

Cerebrovasc Dis. 2005;19(3):147-51. doi: 10.1159/000083247. Epub 2005 Jan 11.


Background: Cerebral venous thromboses (CVT) with distinct clinical presentations have been shown worldwide. However, there is little information regarding race-ethnic differences in this disease.

Methods: We prospectively studied 50 CVT patients from Brazil, comparing clinical and laboratory data among white (W) and African-Brazilian (AB) patients.

Results: Seventy percent of the patients were female, 26 W and 23 AB, mean age 34.7 years. Multiple sinus CVT, deep CVT and worse outcome were significantly more frequent in AB than in W patients. There was a trend towards a higher frequency of factor V Leiden and prothrombin mutation in W than in AB, and of protein C deficiency in AB.

Conclusions: CVT was more severe in AB patients than in W patients. Race-ethnic differences may account for the heterogeneous distribution of inherited thrombophilia in this series.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asian People
  • Black People
  • Brazil / epidemiology
  • Child
  • Cohort Studies
  • Female
  • Humans
  • Intracranial Thrombosis / ethnology*
  • Male
  • Middle Aged
  • Prognosis
  • Risk Factors
  • Urban Population
  • Venous Thrombosis / ethnology*
  • White People