Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases

Acta Neuropathol. 2005 Jan;109(1):14-24. doi: 10.1007/s00401-004-0950-z. Epub 2005 Jan 11.


Modern neuropathologic methods and molecular biology have lead to increased understanding of neurodegenerative disorders and biologically based classifications of these disorders. The purpose of this review is to discuss neuropathologic methods that are useful in the characterization of neurodegenerative disorders, with emphasis on disorders of late life that present with dementia or movement disorders. A diagnostic algorithm is suggested for neuropathologic evaluation of neurodegenerative disorders. The importance of clinical information is emphasized in arriving at the most precise and meaningful neuropathologic diagnosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biomarkers / metabolism*
  • Dementia / metabolism
  • Dementia / pathology*
  • Histocytochemistry / methods
  • Humans
  • Lewy Bodies / pathology
  • Movement Disorders / metabolism
  • Movement Disorders / pathology*
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology*
  • Neurofilament Proteins / metabolism
  • Ubiquitin / metabolism
  • tau Proteins / metabolism


  • Biomarkers
  • Neurofilament Proteins
  • Ubiquitin
  • tau Proteins