Abstract
A biomimetic approach was employed to shed light on the nature of chemical reactions occurring in the covalent inactivation of phospholipase A(2) (PLA(2)) by scalaradial (1), a marine dialdehyde terpenoid endowed with potent anti-inflammatory activity. To this end, a detailed study of the reaction profile between the nitrogenous nucleophile isopropylamine and scalaradial was performed under biologically relevant conditions.
Copyright (c) 2005 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Chromatography, High Pressure Liquid
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Homosteroids / chemistry*
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Phospholipases A / chemistry*
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Phospholipases A2
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Propylamines / chemistry*
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Sesterterpenes
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Spectrometry, Mass, Electrospray Ionization / methods*
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Terpenes / chemistry*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Homosteroids
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Propylamines
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Sesterterpenes
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Terpenes
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scalaradial
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Phospholipases A
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Phospholipases A2
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2-propylamine