Beneficial effects of Bifidobacteria in a gastroresistant seamless capsule on hyperhomocysteinemia in hemodialysis patients

J Ren Nutr. 2005 Jan;15(1):77-80. doi: 10.1053/j.jrn.2004.09.028.


Intestinal microflora is deranged in hemodialysis (HD) patients as an increase in aerobic bacteria such as Escherichia coli and a decrease in anaerobic bacteria such as Bifidobacterium . Bifidobacteria ferment carbohydrates to produce acetic acid and lactic acid, which inhibit the intestinal putrefaction. Thus, intake of Bifidobacteria effectively restores the disturbed microflora to normal. However, Bifidobacteria in most medical products and healthy foods cannot usually survive because of exposure to gastric juices before it reaches the intestines. A gastroresistant seamless capsule prevents Bifidobacteria from inactivation by acidic gastric juice and allows it to be active in the intestines. We showed that the oral administration of Bifidobacterium longum in a gastroresistant seamless capsule to HD patients is effective in decreasing the pre-HD serum levels of homocysteine, indoxyl sulfate, and triglyceride. The reduction in the serum level of homocysteine is mainly attributable to the supply of folate produced by Bifidobacterium longum in the human intestines.

MeSH terms

  • Bifidobacterium / physiology*
  • Capsules
  • Colony Count, Microbial
  • Escherichia coli
  • Folic Acid / biosynthesis*
  • Homocysteine / blood
  • Humans
  • Hyperhomocysteinemia / therapy*
  • Indican / blood
  • Intestines / microbiology*
  • Probiotics*
  • Renal Dialysis / adverse effects*
  • Uremia / microbiology
  • Uremia / therapy


  • Capsules
  • Homocysteine
  • Folic Acid
  • Indican