Basiliximab, mechanism of action and pharmacological properties

Med Arh. 2004;58(6):373-6.

Abstract

Basiliximab is a chimeric anti-intcrleukin-2 receptor monoclonal antibody. Basiliximab is a glycoprotein produced by recombinant technology. It is used to prevent white blood cells from acute renal transplantation rejection. It specifically binds to and blocks the alpha chain of interleukin-2 receptors (IL-2R alpha), also known as CD25 antigen, on the surface of activated T-lymphocytes. Due to its monoclonal nature it provides safer and more predictable therapeutic, that is, immunosuppressive response of the polyclonal antibodies. The most common adverse effects in adult patients are constipation, infections, pain, nausea, peripheral oedema, hypertension, anaemia, headache, hyperkalacmia, hypercholesterolemia, increase in serum creatinine, and hypophosphataemia.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal* / adverse effects
  • Antibodies, Monoclonal* / pharmacokinetics
  • Antibodies, Monoclonal* / pharmacology
  • Basiliximab
  • Graft Rejection / prevention & control
  • Humans
  • Immunosuppressive Agents* / adverse effects
  • Immunosuppressive Agents* / pharmacokinetics
  • Immunosuppressive Agents* / pharmacology
  • Recombinant Fusion Proteins* / adverse effects
  • Recombinant Fusion Proteins* / pharmacokinetics
  • Recombinant Fusion Proteins* / pharmacology

Substances

  • Antibodies, Monoclonal
  • Immunosuppressive Agents
  • Recombinant Fusion Proteins
  • Basiliximab