Serum levels of total dehydroepiandrosterone and total estrone in postmenopausal women with special regard to carcinoma of the uterine corpus

Acta Obstet Gynecol Scand. 1979;58(2):179-81. doi: 10.3109/00016347909154578.

Abstract

Serum levels of total dehydroepiandrosterone and total estrone were determined in 18 postmenopausal women with carcinoma of the uterine corpus (stage I, grade 1-3) and in 40 healthy postmenopausal women. Elevated levels of both steroids were found in the carcinoma group, for dehydroepiandrosterone 2010+/-195 vs. 1299+/-117 nM, p less than 0.01, and for estrone 2,38+/-0.24 vs. 1.36+/-0.11 nM, p less than 0.001. Dehydroepiandrosterone as well as the precursors of estrone are almost exclusively of adrenal origin in the postmenopausal woman. Thus these findings indicate a role of the adrenal cortex in the etiology of corpus carcinoma, either by providing increased levels of substrate for the peripheral synthesis of estrone or a direct action of adrenal androgens on the endometrial tissue.

MeSH terms

  • Aged
  • Dehydroepiandrosterone / blood*
  • Estrone / blood*
  • Female
  • Humans
  • Menopause*
  • Middle Aged
  • Uterine Neoplasms / blood*

Substances

  • Estrone
  • Dehydroepiandrosterone