Factors related to exercise capacity in asymptomatic middle-aged type 2 diabetic patients

Diabetes Res Clin Pract. 2005 Feb;67(2):130-6. doi: 10.1016/j.diabres.2004.06.005.

Abstract

Aim: We aimed to look at the relationship between exercise capacity and metabolic variables in unselected consecutive asymptomatic middle-aged type 2 diabetic patients as a potential marker for undiagnosed coronary heart disease.

Method: Ninety patients (49 +/- 6 years) were included in the study. All patients performed a treadmill exercise test using the Bruce protocol. According to achieved EC, patients were separated into three groups; Group I (n, 24) 8 > metabolic equivalents (METs) > or = 5, Group II (n, 54) 11 > METs > or = 8 and Group III (n, 12) METs > or = 11.

Results: Patients in group I are more likely to be of female gender and to have a family history of coronary heart disease (CHD) than in group III (P = 0.015, P = 0.009, respectively). When compared to group III, patients in group I had higher fasting insulin and fibrinogen levels (P = 0.049 and P = 0.01, respectively). Homeostasis model assessment for insulin resistance (HOMA-IR) index (P = 0.03) was also higher in group I than in group III. We found a significant negative correlation between achieved exercise capacity and age (r = -0.204, P = 0.048), fasting insulin (r = -0.209, P = 0.048), HOMA-IR (r = -0.204, P = 0.048) as well as fibrinogen (r = -0.301, P = 0.007).

Conclusion: Reduced exercise capacity was associated with increased insulin resistance as assessed by HOMA-IR index in asymptomatic middle-aged type 2 diabetic patients.

MeSH terms

  • Adult
  • Coronary Disease / genetics
  • Coronary Disease / physiopathology
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Electrocardiography
  • Exercise / physiology*
  • Exercise Test
  • Fasting
  • Female
  • Fibrinogen / analysis
  • Heart Rate
  • Homeostasis
  • Humans
  • Insulin / blood
  • Insulin Resistance / physiology*
  • Male
  • Middle Aged
  • Obesity / epidemiology
  • Prospective Studies
  • Sex Characteristics
  • Smoking / epidemiology

Substances

  • Insulin
  • Fibrinogen