Expression of Notch in a case of osteosarcoma of the maxilla

Eur J Med Res. 2004 Nov 29;9(11):533-5.


In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Cytoplasm / metabolism
  • Cytoplasm / pathology
  • Humans
  • Immunohistochemistry
  • Male
  • Maxillary Neoplasms / metabolism*
  • Maxillary Neoplasms / pathology
  • Maxillary Neoplasms / surgery
  • Osteosarcoma / metabolism*
  • Osteosarcoma / pathology
  • Osteosarcoma / surgery
  • Receptor, Notch1
  • Receptors, Cell Surface / metabolism*
  • Transcription Factors / metabolism*


  • Biomarkers, Tumor
  • NOTCH1 protein, human
  • Receptor, Notch1
  • Receptors, Cell Surface
  • Transcription Factors