CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer

Ann N Y Acad Sci. 2004 Dec;1028:351-60. doi: 10.1196/annals.1322.041.


CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinical strategies to target CXC chemokines in non-small cell lung cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Chemokines / metabolism
  • Chemokines, CXC / metabolism
  • Chemokines, CXC / physiology*
  • Humans
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / pathology*
  • Models, Biological
  • Neoplasm Metastasis
  • Neoplasms / pathology
  • Neovascularization, Pathologic*
  • RNA, Messenger / metabolism
  • Receptors, Interleukin-8B / metabolism


  • Chemokines
  • Chemokines, CXC
  • RNA, Messenger
  • Receptors, Interleukin-8B