Investigations of the halogen dance reaction on N-substituted 2-thiazolamines

Peter Stanetty; Michael Schnürch; Kurt Mereiter; Marko D Mihovilovic

doi:10.1021/jo0484326

Investigations of the halogen dance reaction on N-substituted 2-thiazolamines

J Org Chem. 2005 Jan 21;70(2):567-74. doi: 10.1021/jo0484326.

Authors

Peter Stanetty¹, Michael Schnürch, Kurt Mereiter, Marko D Mihovilovic

Affiliation

¹ Vienna University of Technology, Institute of Applied Synthetic Chemistry and Institute for Chemical Technology and Analytics, Getreidemarkt 9/163, A-1060 Vienna, Austria. peter.stanetty@tuwien.ac.at

PMID: 15651803
DOI: 10.1021/jo0484326

Abstract

The halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.