Comparison of five different rat models of peripheral nerve injury

Pharmacol Biochem Behav. 2005 Jan;80(1):93-108. doi: 10.1016/j.pbb.2004.10.016. Epub 2004 Nov 24.


Described here is a comparison of five peripheral sciatic nerve injury models in rats which all result in various degrees of neuropathic pain symptoms. They are the chronic constriction injury (CCI), the spinal nerve ligation (SNL), the partial sciatic ligation (PSL), the tibial and sural transection (TST), and the complete sciatic transection (CST) model. Behavioral testing was performed on these models over a 56-day period under strict experimental conditions to minimise variability between the surgical models and to allow for an accurate evaluation of the sensory deficits produced by each model. Overall, all five models of neuropathic pain produced signs of allodynia and hyperalgesia to various stimuli. However, the duration and magnitude of the evoked responses varied considerably between the different models.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Ligation
  • Male
  • Pain Measurement / methods*
  • Peripheral Nerve Injuries*
  • Peripheral Nerves / physiopathology
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Neuropathy / physiopathology
  • Spinal Nerves / injuries
  • Spinal Nerves / physiopathology