Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis

J Neuroimmunol. 2005 Feb;159(1-2):133-6. doi: 10.1016/j.jneuroim.2004.09.011. Epub 2004 Oct 28.


A low prevalence of oligoclonal IgG bands (OB) has been reported as a unique feature of Japanese multiple sclerosis (MS) as compared with Western MS. We compared the frequency of OB between isoelectric focusing (IEF) and agarose gel electrophoresis (AGE) in 59 Japanese patients with clinically definite MS [39 with conventional form of MS (CMS) and 20 with optic-spinal form of MS (OSMS)]. The frequency of IEF-OB in total MS was 54%, whereas that of AGE-OB was only 17%. When OSMS was excluded, the frequency increased to 77% by IEF, whereas it remained 23% by AGE. Our study strongly suggests that IEF is highly effective for detecting OB in Japanese MS patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People
  • Electrophoresis, Agar Gel / methods
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / cerebrospinal fluid*
  • Immunoprecipitation / methods
  • Isoelectric Focusing / methods
  • Male
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Oligoclonal Bands / blood
  • Oligoclonal Bands / cerebrospinal fluid*
  • Optic Nerve / immunology
  • Optic Nerve / pathology
  • Sensitivity and Specificity
  • Silver Staining / methods
  • Spinal Cord / immunology
  • Spinal Cord / pathology


  • Immunoglobulin G
  • Oligoclonal Bands