Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

J Neuroimmunol. 2005 Feb;159(1-2):215-24. doi: 10.1016/j.jneuroim.2004.10.009. Epub 2004 Nov 26.


Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / drug therapy
  • Amyotrophic Lateral Sclerosis / immunology*
  • Amyotrophic Lateral Sclerosis / pathology
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / pathology
  • Cross-Sectional Studies
  • Disease Progression
  • Female
  • Humans
  • Immune System / immunology*
  • Immune System / metabolism
  • Immune System / pathology*
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Immunosuppression Therapy
  • Lymphocyte Activation
  • Macrophage Activation
  • Male
  • Middle Aged
  • Severity of Illness Index


  • Immunoglobulin G
  • Immunoglobulin M