Wnt pathway activation: new relations and locations

Cell. 2005 Jan 14;120(1):11-4. doi: 10.1016/j.cell.2004.12.021.


Recent advances in the Wnt signaling field reveal new components, such as a G protein and an atypical receptor tyrosine kinase, and novel connections between known components. In addition, different subcellular localization of receptors may help to explain distinctions between canonical and noncanonical Wnt pathway activity.

Publication types

  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / metabolism
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / physiology*
  • Wnt Proteins


  • Intercellular Signaling Peptides and Proteins
  • Wnt Proteins
  • Protein-Tyrosine Kinases
  • GTP-Binding Proteins