Population-wide benefits of routine vaccination of children against influenza

Vaccine. 2005 Jan 26;23(10):1284-93. doi: 10.1016/j.vaccine.2004.08.044.

Abstract

Using a stochastic simulation model of influenza transmission, clinical illness, and economic costs, we estimated the population-wide benefits of routinely vaccinating US children (ages 6 months to 18 years) against influenza. Disease burden was projected to decline as a result of both reduced susceptibility to infection among vaccinees and reductions in disease transmission to others in the community. Vaccination of 20% of children would reduce the total number of influenza cases in the US by 46%; 80% coverage would reduce the total number of cases by 91%. Similar reductions were estimated to occur in influenza-related mortality and economic costs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Algorithms
  • Child
  • Child, Preschool
  • Cost Savings
  • Cost of Illness
  • Costs and Cost Analysis
  • Hospitalization / economics
  • Hospitalization / statistics & numerical data
  • Humans
  • Immunization Schedule
  • Infant
  • Influenza Vaccines / economics
  • Influenza Vaccines / therapeutic use
  • Influenza, Human / economics
  • Influenza, Human / immunology*
  • Influenza, Human / prevention & control*
  • Mass Vaccination* / economics
  • Models, Economic
  • Models, Statistical
  • Population
  • Risk Assessment
  • United States / epidemiology

Substances

  • Influenza Vaccines