Homocysteine and retinal vein occlusion: a population-based study

Am J Ophthalmol. 2005 Jan;139(1):181-2. doi: 10.1016/j.ajo.2004.06.084.


Purpose: To report population data on the association between homocysteinemia and retinal vein occlusion (RVO).

Design: Cross-sectional, population-based study.

Methods: Total serum homocysteine (tHcy) was estimated in subjects attending the second Blue Mountains Eye Study (BMES) (n = 3509, aged >49 years). Its association with RVO (graded from retinal photographs) was examined.

Results: Homocysteine was more strongly associated with RVO in younger than older participants. In those aged <70 years, homocysteine levels >15 micromol/l were associated with increased odds of RVO, odds ratio (OR) 3.76; 95% confidence interval (CI) 1.06-13.40, in multivariable-adjusted analyses. Each 1 micromol/l increase in homocysteine was associated with a 7% increased odds of RVO, OR 1.07; CI 0.99-1.17 (P = .08).

Conclusion: This population-based study showed that elevated serum homocysteine is associated with the presence of RVO, independent of other risk factors.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Homocysteine / blood*
  • Humans
  • Hyperhomocysteinemia / blood
  • Hyperhomocysteinemia / complications*
  • Male
  • Middle Aged
  • Odds Ratio
  • Retinal Vein Occlusion / blood
  • Retinal Vein Occlusion / etiology*
  • Risk Factors


  • Homocysteine