SAGA unveiled

Trends Biochem Sci. 2005 Jan;30(1):7-10. doi: 10.1016/j.tibs.2004.11.007.


Transcriptional regulation in eukaryotes is intimately coupled to chromatin dynamics. The SAGA (Spt-Ada-Gcn5) histone acetyltransferase (HAT) complex of Saccharomyces cerevisiae is a multi-subunit co-factor for RNA polymerase II transcription. However, not all gene activation events require its intrinsic HAT activity. In addition, SAGA subunits can also restrict gene transcription. The recently published structural model from the laboratories of Fred Winston and Patrick Schultz of the SAGA complex provides a framework to rationalize these findings and to direct further investigation of this crucial transcriptional co-factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyltransferases / metabolism*
  • Animals
  • Chromatin / metabolism
  • Gene Expression Regulation, Fungal / physiology*
  • Histone Acetyltransferases
  • Humans
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / metabolism*
  • Protein Structure, Quaternary
  • RNA Polymerase II / metabolism
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Transcription, Genetic / physiology
  • Transcriptional Activation


  • Chromatin
  • Multiprotein Complexes
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases
  • RNA Polymerase II