Microbiology. TB--a new target, a new drug

Science. 2005 Jan 14;307(5707):214-5. doi: 10.1126/science.1108379.
No abstract available

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphate / biosynthesis
  • Animals
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Antitubercular Agents / therapeutic use
  • Bacterial Proton-Translocating ATPases / antagonists & inhibitors*
  • Bacterial Proton-Translocating ATPases / chemistry
  • Bacterial Proton-Translocating ATPases / metabolism
  • Clinical Trials, Phase II as Topic
  • Diarylquinolines
  • Drug Design
  • Drug Evaluation, Preclinical
  • Drug Resistance, Bacterial
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Mice
  • Microbial Sensitivity Tests
  • Mycobacterium smegmatis / drug effects
  • Mycobacterium smegmatis / genetics
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / enzymology
  • Mycobacterium tuberculosis / genetics
  • Protein Structure, Secondary
  • Proton-Motive Force
  • Proton-Translocating ATPases / chemistry
  • Proton-Translocating ATPases / metabolism
  • Quinolines / chemistry
  • Quinolines / pharmacology*
  • Quinolines / therapeutic use
  • Tuberculosis / drug therapy*
  • Tuberculosis / microbiology
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Tuberculosis, Multidrug-Resistant / microbiology

Substances

  • Antitubercular Agents
  • Diarylquinolines
  • Enzyme Inhibitors
  • Quinolines
  • bedaquiline
  • Adenosine Triphosphate
  • Bacterial Proton-Translocating ATPases
  • Proton-Translocating ATPases