Anticonvulsant medications extend worm life-span

Science. 2005 Jan 14;307(5707):258-62. doi: 10.1126/science.1105299.

Abstract

Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. These compounds, two of which are approved for human use, are anticonvulsants that modulate neural activity. These compounds also regulated neuromuscular activity in nematodes. These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / drug effects*
  • Aldicarb / pharmacology
  • Animals
  • Anticonvulsants / pharmacology*
  • Anticonvulsants / therapeutic use
  • Caenorhabditis elegans / drug effects*
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / physiology
  • Disorders of Sex Development
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Epilepsy, Absence / drug therapy
  • Ethosuximide / pharmacology*
  • Ethosuximide / therapeutic use
  • Female
  • Forkhead Transcription Factors
  • Genes, Helminth
  • Humans
  • Lactams / pharmacology*
  • Longevity / drug effects*
  • Movement / drug effects
  • Muscles / drug effects
  • Muscles / innervation
  • Muscles / physiology
  • Mutation
  • Neurons / drug effects
  • Neurons / physiology
  • Oviposition / drug effects
  • Pharynx / drug effects
  • Pharynx / physiology
  • Reproduction / drug effects
  • Synaptic Transmission / drug effects
  • Transcription Factors / genetics
  • Transcription Factors / physiology
  • Trimethadione / pharmacology*
  • Trimethadione / therapeutic use
  • Vulva

Substances

  • 3,3-diethyl-2-pyrrolidinone
  • Anticonvulsants
  • Caenorhabditis elegans Proteins
  • Forkhead Transcription Factors
  • Lactams
  • Transcription Factors
  • daf-16 protein, C elegans
  • Ethosuximide
  • Aldicarb
  • Trimethadione