Suppressive Effect of Intravenous Immunoglobulin on Peripheral Blood Neutrophil Count in Patients With Idiopathic Thrombocytopenic Purpura

J Pediatr Hematol Oncol. 2005 Jan;27(1):7-10. doi: 10.1097/01.mph.0000149239.68396.72.


Purpose: To determine the effect of intravenous immunoglobulin (IVIG) on neutrophil count, the authors studied patients with idiopathic thrombocytopenic purpura (ITP).

Patients and methods: Thirty-one of 40 patients with ITP were treated with an IVIG regimen (400 mg/kg/daily for 5 days), while the other 9 were observed without any medications. Peripheral samples were examined during the clinical course.

Results: The absolute neutrophil count in 22 patients with no fever as a side effect decreased significantly by day 2 after the start of IVIG, but in most patients it began to increase soon after the last IVIG. There was also a significant difference between the decreased level of the absolute neutrophil count in patients with and without IVIG. However, re-administration of IVIG within 2 weeks did not significantly suppress the neutrophil count. In contrast, the neutrophil count increased in every patient with a fever as a side effect of IVIG.

Conclusions: IVIG induced a decrease in peripheral blood neutrophil count in patients with ITP.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Fever / etiology
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Infant
  • Leukocyte Count*
  • Neutrophils / drug effects*
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy*


  • Immunoglobulins, Intravenous