Reconstruction of cellular signalling networks and analysis of their properties

Nat Rev Mol Cell Biol. 2005 Feb;6(2):99-111. doi: 10.1038/nrm1570.


The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena
  • Computational Biology / methods*
  • Computer Simulation
  • Humans
  • Models, Biological
  • Models, Molecular
  • Models, Theoretical
  • Protein Interaction Mapping / methods*
  • Signal Transduction*
  • Time Factors