Factors predictive of corneal graft survival. Report from the Australian Corneal Graft Registry

Ophthalmology. 1992 Mar;99(3):403-14. doi: 10.1016/s0161-6420(92)31960-8.


Risk factors for graft failure after penetrating keratoplasty were investigated in 961 patients from records collected prospectively by the Australian Corneal Graft Registry. The most common cause of graft failure was irreversible rejection. A multivariate proportional hazards regression analysis indicated that the key predictors of graft failure were: an indication for graft other than keratoconus or corneal dystrophy; a failed previous graft (ipsilateral eye); aphakia; inflammation at the time of graft; presence of an anterior chamber or iris-clip intraocular lens; graft size outside the range of 7.0 to 7.9 mm diameter; and corneal vascularization occurring in the postoperative period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Australia / epidemiology
  • Child
  • Child, Preschool
  • Corneal Transplantation / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Graft Survival*
  • Humans
  • Keratoplasty, Penetrating* / statistics & numerical data
  • Male
  • Middle Aged
  • Postoperative Complications
  • Proportional Hazards Models
  • Prospective Studies
  • Registries / statistics & numerical data
  • Risk Factors
  • Tissue Donors