Feasibility and diagnostic utility of video capsule endoscopy for the detection of small bowel polyps in patients with hereditary polyposis syndromes

Am J Gastroenterol. 2005 Jan;100(1):27-37. doi: 10.1111/j.1572-0241.2005.40102.x.


Objectives: At present, surveillance of premalignant small bowel polyps in hereditary polyposis syndromes has a number of limitations. Capsule endoscopy (CE) is a promising new method to endoscopically assess the entire length of the small bowel.

Methods: We prospectively examined 40 patients with hereditary polyposis syndromes (29 familial adenomatous polyposis (FAP), 11 Peutz-Jeghers syndrome (PJS)). Results were compared with push-enteroscopy (PE) results in FAP and with esophagogastroduodenoscopy, PE, (MR)-enteroclysis, and surgical specimen in PJS patients.

Results: A total of 76% of the patients with FAP with duodenal adenomas (n = 21) had additional adenomas in the proximal jejunum that could be detected by CE and PE. Moreover, 24% of these FAP patients had further polyps in the distal jejunum or ileum that could only be detected by CE. In contrast, in FAP patients without duodenal polyps (n = 8), jejunal or ileal polyps occurred rarely (12%). CE detected polyps in 10 of 11 patients with PJS, a rate superior to all other reference procedures employed. Importantly, the findings of CE had immediate impact on further clinical management in all PJS patients.

Conclusions: Our results suggest that CE may be of clinical value in selected patients with FAP, whereas in PJS, CE could be used as first line surveillance procedure.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenomatous Polyposis Coli / complications*
  • Adenomatous Polyposis Coli / pathology
  • Adolescent
  • Adult
  • Capsules*
  • Endoscopy, Gastrointestinal*
  • Feasibility Studies
  • Female
  • Humans
  • Intestinal Polyps / etiology
  • Intestinal Polyps / pathology*
  • Intestine, Small / pathology
  • Male
  • Middle Aged
  • Peutz-Jeghers Syndrome / complications*
  • Peutz-Jeghers Syndrome / pathology
  • Prospective Studies
  • Video Recording / instrumentation*


  • Capsules