Nutrient, neural and endocrine control of glucagon-like peptide secretion

Horm Metab Res. Nov-Dec 2004;36(11-12):755-60. doi: 10.1055/s-2004-826159.

Abstract

The intestinal glucagon-like peptides, GLP-1 and GLP-2, are important regulators of nutrient intake, digestion, absorption and metabolism. Extensive studies have shown that the co-secretion of GLP-1 and GLP-2 is regulated by a variety of dietary nutrient, neural and endocrine inputs. Furthermore, secretion of these peptides is altered in a number of pathological conditions, including type 2 diabetes and obesity. The purpose of this review is to discuss the regulation of GLP-1 and GLP-2 secretion in both health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dietary Carbohydrates / administration & dosage*
  • Dietary Fats / administration & dosage*
  • Dietary Proteins / administration & dosage
  • Eating / physiology*
  • Glucagon / metabolism*
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptide 2
  • Humans
  • Neurosecretory Systems / physiology*
  • Obesity / metabolism
  • Peptide Fragments / metabolism*
  • Peptides / metabolism*
  • Protein Precursors / metabolism*

Substances

  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Proteins
  • Glucagon-Like Peptide 2
  • Peptide Fragments
  • Peptides
  • Protein Precursors
  • Glucagon-Like Peptide 1
  • Glucagon