Type-specific reactivity of anti-glycoprotein G antibodies from herpes simplex virus-infected individuals is maintained by single or dual type-specific residues

J Gen Virol. 2005 Feb;86(Pt 2):247-251. doi: 10.1099/vir.0.80656-0.


Glycoprotein G-1 (gG-1) of herpes simplex virus type 1 (HSV-1) and gG-2 of HSV-2 are the only known HSV proteins that induce type-specific human antibody responses. Recently, it was shown that purified human anti-gG-1 and anti-gG-2 antibodies presented a type-specific reactivity to immunogenic stretches with high similarity between gG-1 and gG-2. In this study, the molecular basis for this type-specific recognition was investigated employing synthetic peptides covering the indicated regions, including substitutions of the type-specific residues. The results revealed that single or dual type-specific residues localized within regions of high similarity could induce significant structural differences, explaining the type-specific recognition of the human antibody response to the gG proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Antibodies, Viral / chemistry
  • Antibodies, Viral / immunology*
  • Antibody Specificity
  • Herpes Simplex / blood
  • Herpes Simplex / immunology*
  • Herpesvirus 1, Human / immunology*
  • Herpesvirus 2, Human / immunology*
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides / chemical synthesis
  • Peptides / immunology
  • Viral Envelope Proteins / chemistry
  • Viral Envelope Proteins / immunology*


  • Antibodies, Viral
  • Peptides
  • Viral Envelope Proteins
  • glycoprotein G, herpes simplex virus type 2
  • glycoprotein gG-1, herpes simplex virus type 1