Role of the hedgehog/patched signaling pathway in oncogenesis: a new polymorphism in the PTCH gene in ovarian fibroma

Ann N Y Acad Sci. 2004 Dec;1030:134-43. doi: 10.1196/annals.1329.017.

Abstract

We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibroma and dermoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Primers
  • Female
  • Fibroma / genetics*
  • Genes, Tumor Suppressor / physiology*
  • Hedgehog Proteins
  • Humans
  • Loss of Heterozygosity
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Ovarian Neoplasms / genetics*
  • Patched Receptors
  • Patched-1 Receptor
  • Polymorphism, Genetic*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / physiology*
  • Trans-Activators / physiology*

Substances

  • DNA Primers
  • Hedgehog Proteins
  • Membrane Proteins
  • PTCH protein, human
  • Patched Receptors
  • Patched-1 Receptor
  • Receptors, Cell Surface
  • SHH protein, human
  • Trans-Activators