Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure

AIDS Patient Care STDS. 2004 Dec;18(12):687-90. doi: 10.1089/apc.2004.18.687.


We encountered a 49-year-old HIV-infected man with chronic renal insufficiency who developed rhabdomyolysis after treatment with simvastatin. He recovered after initiating hemodialysis and discontinuing oral medications. Rhabdomyolysis most likely resulted from an excessive blood concentration of simvastatin caused by concomitant use of fluconazole in the presence of renal insufficiency.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Anticholesteremic Agents / adverse effects*
  • Female
  • HIV Infections / complications
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / drug therapy*
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Renal Dialysis
  • Rhabdomyolysis / chemically induced*
  • Simvastatin / adverse effects*


  • Anticholesteremic Agents
  • Simvastatin