Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Filters applied. Clear all
. 2005 Mar;116(4):279-91.
doi: 10.1007/s00439-004-1201-z. Epub 2005 Jan 20.

Signature of Recent Historical Events in the European Y-chromosomal STR Haplotype Distribution


Signature of Recent Historical Events in the European Y-chromosomal STR Haplotype Distribution

Lutz Roewer et al. Hum Genet. .


Previous studies of human Y-chromosomal single-nucleotide polymorphisms (Y-SNPs) established a link between the extant Y-SNP haplogroup distribution and the prehistoric demography of Europe. By contrast, our analysis of seven rapidly evolving Y-chromosomal short tandem repeat loci (Y-STRs) in over 12,700 samples from 91 different locations in Europe reveals a signature of more recent historic events, not previously detected by other genetic markers. Cluster analysis based upon molecular variance yields two clearly identifiable sub-clusters of Western and Eastern European Y-STR haplotypes, and a diverse transition zone in central Europe, where haplotype spectra change more rapidly with longitude than with latitude. This and other observed patterns of Y-STR similarity may plausibly be related to particular historical incidents, including, for example, the expansion of the Franconian and Ottoman Empires. We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history.

Similar articles

  • Recent radiation within Y-chromosomal haplogroup R-M269 resulted in high Y-STR haplotype resemblance.
    Larmuseau MH, Vanderheyden N, Van Geystelen A, van Oven M, de Knijff P, Decorte R. Larmuseau MH, et al. Ann Hum Genet. 2014 Mar;78(2):92-103. doi: 10.1111/ahg.12050. Ann Hum Genet. 2014. PMID: 24571229
  • Geostatistical inference of main Y-STR-haplotype groups in Europe.
    Diaz-Lacava A, Walier M, Willuweit S, Wienker TF, Fimmers R, Baur MP, Roewer L. Diaz-Lacava A, et al. Forensic Sci Int Genet. 2011 Mar;5(2):91-4. doi: 10.1016/j.fsigen.2010.09.010. Forensic Sci Int Genet. 2011. PMID: 20970399
  • Excavating Y-chromosome haplotype strata in Anatolia.
    Cinnioğlu C, King R, Kivisild T, Kalfoğlu E, Atasoy S, Cavalleri GL, Lillie AS, Roseman CC, Lin AA, Prince K, Oefner PJ, Shen P, Semino O, Cavalli-Sforza LL, Underhill PA. Cinnioğlu C, et al. Hum Genet. 2004 Jan;114(2):127-48. doi: 10.1007/s00439-003-1031-4. Epub 2003 Oct 29. Hum Genet. 2004. PMID: 14586639
  • Male-specific contributions to the Brazilian population of Espirito Santo.
    de F Figueiredo R, Ambrosio IB, Braganholi DF, Chemale G, Martins JA, Gomes V, Gusmão L, Cicarelli RM. de F Figueiredo R, et al. Int J Legal Med. 2016 May;130(3):679-81. doi: 10.1007/s00414-015-1214-2. Epub 2015 Jun 16. Int J Legal Med. 2016. PMID: 26076592 Review.
  • Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.
    Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A, Wilson Sayres MA, Ayub Q, McCarthy SA, Narechania A, Kashin S, Chen Y, Banerjee R, Rodriguez-Flores JL, Cerezo M, Shao H, Gymrek M, Malhotra A, Louzada S, Desalle R, Ritchie GR, Cerveira E, Fitzgerald TW, Garrison E, Marcketta A, Mittelman D, Romanovitch M, Zhang C, Zheng-Bradley X, Abecasis GR, McCarroll SA, Flicek P, Underhill PA, Coin L, Zerbino DR, Yang F, Lee C, Clarke L, Auton A, Erlich Y, Handsaker RE; 1000 Genomes Project Consortium, Bustamante CD, Tyler-Smith C. Poznik GD, et al. Nat Genet. 2016 Jun;48(6):593-9. doi: 10.1038/ng.3559. Epub 2016 Apr 25. Nat Genet. 2016. PMID: 27111036 Free PMC article. Review.
See all similar articles

Cited by 49 articles

See all "Cited by" articles


    1. Int J Legal Med. 1997;110(3):125-33, 141-9 - PubMed
    1. Nat Rev Genet. 2003 Aug;4(8):598-612 - PubMed
    1. Science. 2000 Nov 10;290(5494):1155-9 - PubMed
    1. Nat Genet. 1998 Nov;20(3):278-80 - PubMed
    1. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11008-13 - PubMed

LinkOut - more resources