Multiple avascular necrosis in a patient with systemic lupus erythematosus/systemic sclerosis overlap syndrome

Clin Rheumatol. 2005 Aug;24(4):406-8. doi: 10.1007/s10067-004-1048-7. Epub 2005 Jan 20.


A white female patient developed overlapping features of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) with severe pulmonary compromise. She was treated with steroids and azathioprine, which improved her clinical condition and spirometric status. In May 2002 she presented with continuous pain in her left ankle that continued even during rest and under treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). Magnetic resonance imaging (MRI) showed multiple avascular necrosis (AVN). Rest and kinesitherapy were indicated for 1 year, and gradually an orthosis was introduced allowing the patient to walk normally.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Follow-Up Studies
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis*
  • Magnetic Resonance Imaging / methods
  • Microscopic Angioscopy
  • Orthotic Devices
  • Osteonecrosis / complications
  • Osteonecrosis / diagnosis*
  • Osteonecrosis / rehabilitation
  • Pain Measurement
  • Risk Assessment
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / diagnosis*
  • Severity of Illness Index
  • Syndrome
  • Tomography, X-Ray Computed