Targeting key steps in metastatic tumour progression

Curr Opin Genet Dev. 2005 Feb;15(1):77-86. doi: 10.1016/j.gde.2004.12.001.


The key determinants of tumour progression and discriminators of benign and malignant lesions include neoangiogenesis (the induction of a new blood supply) and the capacity of malignant cells to invade and metastasise. It is now recognized that these processes can be co-ordinately regulated by the activity of specific genes -- often distinct from those involved in early oncogenesis -- and involve common signalling pathways. Cell motility and chemotaxis (the ability to respond to gradients of chemoattractants) are implicated in both tumour-cell invasion and response of activated endothelial cells to angiogenic cytokines, and provide interesting and novel points for therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Chemokines / metabolism
  • Humans
  • Hypoxia / metabolism
  • Neoplasm Invasiveness
  • Neoplasm Metastasis*
  • Neovascularization, Pathologic / metabolism*
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction / physiology


  • Chemokines
  • Receptors, G-Protein-Coupled
  • Receptor Protein-Tyrosine Kinases