Mechanisms of cancer cell invasion

Curr Opin Genet Dev. 2005 Feb;15(1):87-96. doi: 10.1016/j.gde.2004.12.002.


The movement of cancer cells into tissue surrounding the tumour and the vasculature is the first step in the spread of metastatic cancers. Recent advances in imaging, the use of 3D model systems and the application of microarray technologies have yielded new insights into these processes. This work has challenged our views about what causes cancer cells to become motile in the first place, and has demonstrated that cancer cells can move in many different ways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Gene Expression Regulation, Neoplastic / physiology
  • Humans
  • Mutation
  • Neoplasm Invasiveness / genetics
  • Neoplasm Invasiveness / pathology*
  • Neoplasm Invasiveness / prevention & control
  • Neoplasms / drug therapy
  • Neoplasms / pathology