Getting to the heart of visual loss: when cardiac medication may be dangerous to the optic nerves

Surv Ophthalmol. 1992 Mar-Apr;36(5):366-72. doi: 10.1016/0039-6257(92)90114-9.


A 62-year-old lady with hypertension and diabetes developed bilateral, sequential ischemic optic neuropathy, progressive in the right eye. Because of a reported association between amiodarone and optic neuropathy with disc edema, the patient discontinued taking this medication; however, her visual loss continued. The differential diagnoses of bilateral ischemic optic neuropathy--including infiltrative optic neuropathy and temporal arteritis--were exhaustively investigated in this patient.

Publication types

  • Case Reports
  • Clinical Conference
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amiodarone / adverse effects*
  • Amiodarone / therapeutic use
  • Arrhythmias, Cardiac / drug therapy
  • Diagnosis, Differential
  • Female
  • Fundus Oculi
  • Giant Cell Arteritis / chemically induced
  • Giant Cell Arteritis / diagnosis
  • Humans
  • Ischemia / chemically induced*
  • Ischemia / diagnosis
  • Middle Aged
  • Optic Nerve / blood supply
  • Optic Nerve Diseases / chemically induced*
  • Optic Nerve Diseases / diagnosis
  • Papilledema / chemically induced
  • Vision Disorders / chemically induced*
  • Vision Disorders / diagnosis
  • Visual Acuity


  • Amiodarone