Determinants of small solute clearance in hemodialysis

Semin Dial. Jan-Feb 2005;18(1):30-5. doi: 10.1111/j.1525-139X.2005.18101.x.


Recent outcome trials in chronic dialysis patients raise concerns about the relationship between delivered urea Kt/V and survival. Nevertheless, measurement of delivered small solute clearance remains the most common approach to quantify therapy. The purpose of this review is to provide an overview of the numerous factors influencing small solute clearance during hemodialysis. Although the focus of the review is on the manner in which dialyzer characteristics influence small solute clearances, factors related to other aspects of the extracorporeal circuit and to the patient will also be discussed.

Publication types

  • Review

MeSH terms

  • Blood Urea Nitrogen
  • Dialysis Solutions / metabolism*
  • Humans
  • Kidney Failure, Chronic / metabolism*
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy
  • Renal Circulation
  • Renal Dialysis*
  • Urea / metabolism*


  • Dialysis Solutions
  • Urea