Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats

Neurosci Lett. 2005 Feb 21;374(3):183-8. doi: 10.1016/j.neulet.2004.10.070. Epub 2004 Nov 23.

Abstract

The present study evaluated the neuroprotective effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent and more recently as a heat shock protein (HSP) inducer, against cerebral infarction induced by permanent left middle cerebral artery (MCA) occlusion. GGA was given orally in various regimens prior to MCA occlusion in rats. Pretreatment with a single oral GGA dose (800 mg/kg) 48 h before ischemia significantly attenuated cerebral infarction volume (81.7+/-18.4 mm3 versus 369.1+/-70.2 mm3; P<.01). A significant increase in HSP70 immunoreactivity was found in the neocortex in GGA-treated animals with or without ischemia. Pretreatment with a single oral dose of GGA provides an important tool for exploring the mechanisms of neuroprotection against cerebral ischemic neuronal damage.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebral Infarction / etiology
  • Cerebral Infarction / metabolism
  • Cerebral Infarction / pathology
  • Cerebral Infarction / prevention & control*
  • Diterpenes / therapeutic use*
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation / drug effects
  • HSP70 Heat-Shock Proteins / metabolism
  • Immunohistochemistry / methods
  • Infarction, Middle Cerebral Artery / complications
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Infarction, Middle Cerebral Artery / metabolism
  • Infarction, Middle Cerebral Artery / pathology
  • Male
  • Neurologic Examination
  • Neuroprotective Agents / therapeutic use*
  • Rats
  • Tetrazolium Salts
  • Time Factors

Substances

  • Diterpenes
  • HSP70 Heat-Shock Proteins
  • Neuroprotective Agents
  • Tetrazolium Salts
  • triphenyltetrazolium
  • geranylgeranylacetone