Heterochromatin focuses on senescence

Mol Cell. 2005 Jan 21;17(2):168-70. doi: 10.1016/j.molcel.2005.01.003.


A key step in cellular senescence is the packaging of proliferation-promoting genes into repressive chromatin or heterochromatin. Recent work has described a novel histone component and mode of assembly of this senescence-associated heterochromatin.

MeSH terms

  • Cell Proliferation
  • Cellular Senescence / genetics*
  • Heterochromatin / metabolism*
  • Histones / metabolism*
  • Humans
  • Models, Genetic
  • Nucleic Acid Conformation


  • Heterochromatin
  • Histones
  • macroH2A histone