Cyclosporine protects against ischemia/reperfusion injury in rat kidneys

Toxicology. 2005 Feb 28;207(3):339-47. doi: 10.1016/j.tox.2004.09.018.

Abstract

Renal ischemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allografts. Cyclosporine A (CsA) has been used as an immunosuppressive agent in organ transplantation. In the present study, the effect of CsA on ischemia/reperfusion (I/R)-induced injury in the kidney was investigated. Ischemia/reperfusion injury caused a significant deterioration in the renal function, morphology and gave rise to a severe oxidative stress in the kidney. At 3 mg/kg i.v., CsA significantly improved the functional and histological parameters and attenuated the oxidative stress induced by renal ischemia/reperfusion. From the results of our study, it can be concluded that low-dose CsA pretreatment preconditions the rat kidneys against subsequent ischemia/reperfusion injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclosporine / administration & dosage
  • Cyclosporine / pharmacology
  • Cyclosporine / therapeutic use*
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*
  • Injections, Intravenous
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Function Tests
  • Male
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Oxidative Stress / drug effects
  • Rats
  • Rats, Wistar
  • Reperfusion Injury / pathology
  • Reperfusion Injury / physiopathology
  • Reperfusion Injury / prevention & control*
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Immunosuppressive Agents
  • Thiobarbituric Acid Reactive Substances
  • Cyclosporine