Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 15 (3), 699-703

Discovery and Structure-Activity Relationships of Novel Selective Norepinephrine and Dual Serotonin/Norepinephrine Reuptake Inhibitors

Affiliations

Discovery and Structure-Activity Relationships of Novel Selective Norepinephrine and Dual Serotonin/Norepinephrine Reuptake Inhibitors

John Boot et al. Bioorg Med Chem Lett.

Abstract

Novel arylthiomethyl morpholines are potent selective norepinephrine reuptake inhibitors (NERIs) and dual serotonin/norepinephrine reuptake inhibitors (SRI/NERIs). The target compounds were prepared using a stereochemically versatile synthesis featuring an aldol condensation as the key step. One enantiomer of the 2-methoxy-substituted analogue was found to be a potent and selective norepinephrine reuptake inhibitor, whereas the opposite enantiomer was a potent dual serotonin/norepinephrine reuptake inhibitor.

Similar articles

See all similar articles

Cited by 4 articles

MeSH terms

LinkOut - more resources

Feedback