Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes

Infect Immun. 2005 Feb;73(2):1209-13. doi: 10.1128/IAI.73.2.1209-1213.2005.

Abstract

Peroxisome proliferator-activated receptor gamma-retinoid X receptor (PPARgamma-RXR) agonists had minimal effects on the surface levels of CD36, intercellular cell adhesion molecule-1, or platelet-endothelial cell adhesion molecule-1 and had no effect on the cytoadherence of infected erythrocytes to either human umbilical vein endothelial cells or human microvascular endothelial cells or on malaria-induced interleukin-6 secretion from these cells. PPARgamma-RXR agonists do not significantly modify malaria-infected erythrocyte-endothelial cell interactions in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers
  • Cell Adhesion / physiology
  • Endothelial Cells / physiology*
  • Erythrocytes / parasitology*
  • Erythrocytes / physiology
  • Flow Cytometry
  • Humans
  • PPAR gamma / agonists*
  • Plasmodium falciparum*
  • Retinoid X Receptors / agonists*

Substances

  • Biomarkers
  • PPAR gamma
  • Retinoid X Receptors