The relationship between epilepsy and schizophrenia: a biochemical hypothesis

Biol Psychiatry. 1977 Apr;12(2):299-304.


There has been much controversy in the past surrounding the relationship between schizophrenia and epilepsy. One hypothesis has been that the two disorders are antagonistic. The evidence supporting the antagonism hypothesis is briefly reviewed. A new theory based on current knowledge of the relationship of dopamine to both disorders is postulated which may explain the relationship between the psychosis and epilepsy which occurs in a subgroup of schizophrenic patients. In the light of this hypothesis it is suggested that further clinical work be undertaken to clarify further the exact association between the two disorders.

MeSH terms

  • Amphetamines / adverse effects
  • Antipsychotic Agents / pharmacology
  • Brain / metabolism*
  • Dopamine / metabolism*
  • Epilepsy / metabolism*
  • Humans
  • Levodopa / pharmacology
  • Phenothiazines
  • Psychoses, Substance-Induced / etiology
  • Receptors, Dopamine / drug effects
  • Schizophrenia / metabolism*


  • Amphetamines
  • Antipsychotic Agents
  • Phenothiazines
  • Receptors, Dopamine
  • Levodopa
  • Dopamine