Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice

Biosci Biotechnol Biochem. 2005 Jan;69(1):209-11. doi: 10.1271/bbb.69.209.


Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.

MeSH terms

  • 1,2-Dimethylhydrazine
  • Animals
  • Cell Proliferation / drug effects*
  • Colon / pathology
  • Colonic Diseases / chemically induced
  • Colonic Diseases / pathology
  • Colonic Diseases / prevention & control*
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Mice, Inbred Strains
  • Pyrazoles / pharmacology*
  • Xanthine Oxidase / antagonists & inhibitors*


  • 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid
  • Pyrazoles
  • Xanthine Oxidase
  • 1,2-Dimethylhydrazine