Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells

Biosci Biotechnol Biochem. 2005 Jan;69(1):224-7. doi: 10.1271/bbb.69.224.


Apoptosis induced by fucoxanthin in HL-60 cells was associated with a loss of mitochondrial membrane potential at an early stage, but not with an increase in reactive oxygen species. Fucoxanthin treatment caused cleavages of procaspase-3 and poly (ADP-ribose) polymerase without any effect on the protein level of Bcl-2, Bcl-X(L), or Bax. Apoptosis induction by fucoxanthin may be mediated via mitochondrial membrane permeabilization and caspase-3 activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Caspase 3
  • Caspases / metabolism
  • Cell Line, Tumor
  • Humans
  • Intracellular Membranes / drug effects
  • Leukemia, Promyelocytic, Acute
  • Mitochondria / drug effects
  • Poly(ADP-ribose) Polymerases / metabolism
  • Reactive Oxygen Species
  • Xanthophylls / pharmacology*


  • Anticarcinogenic Agents
  • Reactive Oxygen Species
  • Xanthophylls
  • fucoxanthin
  • Poly(ADP-ribose) Polymerases
  • CASP3 protein, human
  • Caspase 3
  • Caspases